Duromine vs Sibutramine

Duromine and Sibutramine are two drugs used to treat obesity in conjunction with diet and physical activity. The action of both drugs is to suppress the feeling of hunger, as well as they can be used in such related diseases as high blood pressure or diabetes.

Sibutramine is available as capsules of 5, 10, 15 and 30 mg and can be used for a long time, up to two years. Duromine is produced in tablets of 15, 30 and 40 mg and is intended as a short-term use no longer than three months.

Sibutramine 20mgThe minimal daily dose of Sibutramine is 5 mg taken in the morning.

Use of Sibutramine is recommended for patients aged 16 to 65 years.
The usual dose of Duromine is 30 mg per day taken in the morning during breakfast.

Duromine is not recommended for children under 12 years of age and older people.

If patients taking Sibutramine failed to lose at least two kilos during the first month of use, increase in the dose or discontinuation of the drug can be recommended.

If the patient failed to lose at least 5% of the initial body weight after three months of using Duromine, the drug use should be stopped.
Both drugs help to treat obesity by reducing the feeling of hunger and, accordingly, increase of saturation. To achieve the maximum effect from the use of Sibutramine and Duromine, the drugs should be combined with diet therapy and physical activity.

Duromine has impact on the hypothalamus, the brain region that controls important functions of the body, including appetite. Duromine also affects the central nervous system and heart rate.

Just as Duromine, Sibutramine reduces the feeling of hunger by influencing on appetite control center in the brain.
However, unlike Duromine, Sibutramine affects adipose tissue, rather than the central nervous system, i.e. promotes intense burning of fat deposits.

  1. The obvious advantages of Sibutramine over Duromine are achievement the desired effect using a lower dose (5 mg vs 15mg) and the possibility to use it for longer period (two years vs 3 months).
  2. In addition, active ingredient Phentermine contained in Duromine is a stimulant and may cause drug dependence in case of overdose.
  3. Drinking alcohol is contraindicated while using Duromine, since the risk of side effects from the central nervous system such as confusion, lightheadedness or dizziness increases.
  4. Simultaneous use of alcohol and Sibutramine does not lead to any negative consequences, but herewith alcohol weakens therapeutic properties of Sibutramine when treating obesity.

Duromine should not be taken with other drugs, the effect of which also lies in appetite suppression. There are no reliable clinical data, which would demonstrate benefit or harm of simultaneous use of Sibutramine and other means for obesity.